Research Interest: Our laboratory is designing novel molecules targeting RNA, RNA-binding proteins, and disease-associated protein complexes to address unmet medical needs. We specialize in induced-proximity strategies, including molecular glues and bifunctional chimeras, to selectively modulate or eliminate pathogenic targets in cancer and other complex diseases. In the context of the Multidisciplinary Center for Cannabinoid Research, we focus on targeting the CB1 receptor and developing molecules that induce its selective degradation as a novel therapeutic approach for cancer and metabolic diseases associated with CB1R dysregulation.
Research Interest: We are interested in drug development and drug delivery of Cannabinoid product. Using multideciplinary approach of formulation development, tumor cell assays and in-vivo models we will study efficacy and pharmacological properties of cannabinoids.
Research Interests: The main goal of my lab is to study how pain- and itch-related information is encoded and transmitted by the peripheral and central neurons in normal and pathological conditions. Based on the understanding of the molecular and biophysical mechanisms of detection and transmission of noxious stimuli we also aim to develop new approaches for selective targeting pain- and itch-generating neurons as well as tumor cells.
Research Interest: Cannabis and anesthesia/ cannabis and acute and chronic pain/ long acting local anesthetics/ bench to market cannabis clinical research
Keywords: cannabis, pain, anesthesia, local anesthesia.
Research Interest: Skeletal mobility is largely dependent on the function of our joints. The thin hyaline cartilage layer covering our bones form cushions that allow us to comfortably perform all types of physical activities. Aside from these functions, healthy cartilage is required for normal skeletal development and throughout our lives protects bones from erosion, by functioning as a shock absorber during moderate or intense activity. Our lab is exploring the myriad roles of the endocannabinoid system and sirtuins within the the context of cartilage biology, during aging and skeletal development.
Research Interest: We are interested in various aspects of the cannabinoid system in patients with epilepsy and in cannabinoid distribution within the human body.
Research Interest: Modeling small molecule activities at protein targets by using physico-chemical properties of ligands to distinguish and classify active molecules from inactive or from less active ones, a "model" being a large set of molecular property filters each having a different ability for classification.
Scoring of molecules is achieved by virtual screening huge molecular databases through the filters and discovering novel active molecular scaffolds. A major interest is in "multitargeting", i.e., discovering single molecules that act at two or more protein targets and avoid antitargets. We focus on main CNS GPCRs.
Research Interest: Our lab is focused on investigating the cardiovascular safety of medical cannabis, particularly given its increasing use among oncology patients and the gaps in current cardiovascular safety data.
Key Words: cardiovascular safety, medical cannabis, CBD, THC, oncology, anthracycline, immune check point inhibitors, cancer, cardiotoxicity.
Research Interest: The main theme of our lab is to optimize drug therapy according to pharmacokinetics and pharmacodynamics principles. This is based on both clinical and preclinical investigations, with special interests in the biological aspects of drug delivery systems.
Research Interest: The role of endocannabinoids in allergic inflammation and the role of endocannabinoids in synergism with pro-resolving lipid mediators in resolution of allergic inflammation.
Research Interest: The main focus of the research in our lab is plant-pathogen interactions. We study the plant's defense responses against the fungal plant-pathogen Botrytis cinerea. Structural defense, chemical defense and plant induced resistance via the biocontrol agents Pseudozyma aphidis.
Research Interest: Safety and efficacy of medical cannabinoids
Specific Research Topics on Cannabinoids:
To evaluate the safety and efficacy profile of medical cannabinoids in children in children with refractory epilepsy, chemotherapy-induced nausea and vomit, and autism.
To characterize the population at risk for negative mental emotions in adults exposed to cannabis.
To evaluate the risk of mental illness in medical cannabis patients.
Key Words: medical cannabis, mental health, psychosis, schizophrenia, children
Capabilities for Scientific Collaborations and Services
Research Interest: The influence of different cannabinoids on hematopoiesis after hematopoietic stem cell transplantation. The use of different cannabinoids and cannabis products as a treatment for Graft versus host disease.
Research Interest: The main goal of our lab is to explore the effects of cannabinoids on the mammalian gametes. In particular, to examine the effect of cannabinoids on intracellular and molecular mechanisms during oocyte maturation and sperm capacitation, with a follow up on fertilization capability and embryonic development.
Research Interest: I have a broad background in oncology, geriatrics, bio-statistics and medical innovation. Since I established a cannabis clinic in 2013, more than 3,100 licenses have been granted for the medical use of cannabis combined with conducting a clinical trial in early order to assess the impact of cannabinoids on solid tumors (ClinicalTrials.gov, NCT02255292), in collaboration with Prof. Rafael Meshulam.
Research Interest: We are interested in the chronic effect of THC in an obese setting, specifically how it impacts metabolic diseases associated with obesity.
Specific Research Topics on Cannabinoids:
Each research topic must be presented by an abstract in the “Research Projects” section
The antiviral activity of CBD. Since we find viruses in Alzheimer’s disease brains, and since CBD has known antiviral activity, we would like to test the therapeutic potential of cannabinoids against brain-infecting viruses.
Research Interest: Shoseyov laboratory has been working on NIR spectrometry, remote sensing and machine learning of cannabis chemical composition and genetic markes.
Research Interest: Our lab focuses on understand fundamental questions such as affinity and reactivity in chemistry and biochemistry using different computational methods.
Research Interest: The main research trust of the lab is microbes attached to surfaces (biofilms). We investigate “life” in the biofilm as each biofilm differs from another. We examine microbes immobilized in biofilm on: transcriptomic, proteomic, metabolomic, levels using techniques as computational analysis alongside with biochemical methods. Next, we develop new means to affect the biofilm (drugs and drug delivery technologies). Among them are cannabinoids and endocannabinoids.
Research Interest: Our lab is focused on uncovering the involvement of the endocannabinoid system in the pathogenesis of obesity and its metabolic complications, with therapeutic prospects for the development of an effective drug therapy.
Research Interest: My research focuses on elucidating the neurobiological basis of major psychiatric disorders: depression, anxiety, and PTSD. We apply cutting-edge molecular, cellular, and circuit-level technologies to map disease-relevant changes with high precision and pinpoint convergent mechanisms shared across these highly comorbid conditions. Our ultimate goal is to translate these discoveries into novel, mechanism-based drug targets and therapeutic strategies that can more effectively prevent or treat stress- and trauma-related psychiatric illness.
Research interest: Understanding the molecular mechanism that underlies the neuroprotective effects of the cannabinoid system in different pathophysiological conditions.
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