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Research Interest: Alterations of the endocannabinoid system in autism spectrum disorder (ASD) and other neurodevelopmental disorders and exploration of possible therapeutic effects of phytocannabinoids and terpenoids in these disorders.
Research Interest: We are interested in drug development and drug delivery of Cannabinoid product. Using multideciplinary approach of formulation development, tumor cell assays and in-vivo models we will study efficacy and pharmacological properties of cannabinoids.
Research Interests: The main goal of my lab is to study how pain- and itch-related information is encoded and transmitted by the peripheral and central neurons in normal and pathological conditions. Based on the understanding of the molecular and biophysical mechanisms of detection and transmission of noxious stimuli we also aim to develop new approaches for selective targeting pain- and itch-generating neurons as well as tumor cells.
Research Interest: I am interested in understanding key molecular pathways in articular cartilage affected by the endocannabinoid system or cannabinoids at large. My work focuses on the highly prevalent age-associated diseases of the joint called Osteoarthritis.
Specific Research Topics on Cannabinoids:
Studying the effect on D9-THC on post-traumatic OA development
Studying the effect on D9-THC on age-related OA development
Research Interest: We are interested in investigating various aspects of the cannabinoid system in patients with epilepsy and in animal models of epilepsy.
Research Interest: Modeling small molecule activities at protein targets by using physico-chemical properties of ligands to distinguish and classify active molecules from inactive or from less active ones, a "model" being a large set of molecular property filters each having a different ability for classification.
Scoring of molecules is achieved by virtual screening huge molecular databases through the filters and discovering novel active molecular scaffolds. A major interest is in "multitargeting", i.e., discovering single molecules that act at two or more protein targets and avoid antitargets. We focus on main CNS GPCRs.
Research Interest: Targeting of nanoparticles containing cannabinoids/endocannabinoids to specific organs/tissues, and studying their effect on monocytes/macrophages.
Research Interest: To study the cardiovascular effect (left ventricular [LV] function, myocardial injury and arrhythmia) of cannabis consumption in patients at high risk for cardiovascular events.
Specific Research Topics on Cannabinoids:
Cardiovascular effects of cannabis exposure in patients treated with Anthracycline
Research Interest: The main theme of our lab is to optimize drug therapy according to pharmacokinetics and pharmacodynamics principles. This is based on both clinical and preclinical investigations, with special interests in the biological aspects of drug delivery systems.
Research Interest: The role of endocannabinoids in allergic inflammation and the role of endocannabinoids in synergism with pro-resolving lipid mediators in resolution of allergic inflammation.
Research Interest: The main focus of the research in our lab is plant-pathogen interactions. We study the plant's defense responses against the fungal plant-pathogen Botrytis cinerea. Structural defense, chemical defense and plant induced resistance via the biocontrol agents Pseudozyma aphidis.
Research Interest: Safety and efficacy of medical cannabinoids
Specific Research Topics on Cannabinoids:
To evaluate the safety and efficacy profile of medical cannabinoids in children in children with refractory epilepsy, chemotherapy-induced nausea and vomit, and autism.
To characterize the population at risk for negative mental emotions in adults exposed to cannabis.
To evaluate the risk of mental illness in medical cannabis patients.
Key Words: medical cannabis, mental health, psychosis, schizophrenia, children
Capabilities for Scientific Collaborations and Services
Research Interest: My laboratory has worked on the chemistry, pharmacology and clinical effects of natural products (including cannabis) for over 50 years. We have isolated numerous cannabinoids, including the active constituent of cannabis, delta9-THC, and elucidated its structure. We have also identified endogenous cannabinoids in the pig brain. These fatty acid derivatives, named anandamide and 2-AG, are the agonists of a major new biological system called the endocannabinoid system. Most of my current research focuses on the numerous anandamide-like compounds in the mammalian body, many of which are involved in basic biological reactions, such as bone formation, vasodilation, head trauma, addiction, etc. We have also developed novel cannabinoids and anandamide-like compounds which are being developed as drugs by pharma companies.
Research Interest: The influence of different cannabinoids on hematopoiesis after hematopoietic stem cell transplantation. The use of different cannabinoids and cannabis products as a treatment for Graft versus host disease.
Research Interest: The main goal of our lab is to explore the effects of cannabinoids on the mammalian gametes. In particular, to examine the effect of cannabinoids on intracellular and molecular mechanisms during oocyte maturation and sperm capacitation, with a follow up on fertilization capability and embryonic development.
Research Interest: I have a broad background in oncology, geriatrics, bio-statistics and medical innovation. Since I established a cannabis clinic in 2013, more than 3,100 licenses have been granted for the medical use of cannabis combined with conducting a clinical trial in early order to assess the impact of cannabinoids on solid tumors (ClinicalTrials.gov, NCT02255292), in collaboration with Prof. Rafael Meshulam.
Research Interest: We are interested in the chronic effect of THC in an obese setting, specifically how it impacts metabolic diseases associated with obesity.
Specific Research Topics on Cannabinoids:
Each research topic must be presented by an abstract in the “Research Projects” section
The antiviral activity of CBD. Since we find viruses in Alzheimer’s disease brains, and since CBD has known antiviral activity, we would like to test the therapeutic potential of cannabinoids against brain-infecting viruses.
Research Interest: Shoseyov laboratory has been working on NIR spectrometry, remote sensing and machine learning of cannabis chemical composition and genetic markes.
Research Interest: Our lab focuses on understand fundamental questions such as affinity and reactivity in chemistry and biochemistry using different computational methods.
Research Interest: Our lab is focused on uncovering the involvement of the endocannabinoid system in the pathogenesis of obesity and its metabolic complications, with therapeutic prospects for the development of an effective drug therapy. Research Topics on Cannabinoids:
Research interest: Understanding the molecular mechanism that underlies the neuroprotective effects of the cannabinoid system in different pathophysiological conditions.
