Raphael Mechoulam Ph.D.
Head, Multidisciplinary Center for Cannabinoid Research
Research Interest: My laboratory has worked on the chemistry, pharmacology and clinical effects of natural products (including cannabis) for over 50 years. We have isolated numerous cannabinoids, including the active constituent of cannabis, delta9-THC, and elucidated its structure. We have also identified endogenous cannabinoids in the pig brain. These fatty acid derivatives, named anandamide and 2-AG, are the agonists of a major new biological system called the endocannabinoid system. Most of my current research focuses on the numerous anandamide-like compounds in the mammalian body, many of which are involved in basic biological reactions, such as bone formation, vasodilation, head trauma, addiction, etc. We have also developed novel cannabinoids and anandamide-like compounds which are being developed as drugs by pharma companies.
Specific Research Topics on Cannabinoids:
Key Words: Tetrahydrocannabinol; Cannabidiol; Anandamide; 2-AG; Oleoyl-serine.