Research Interest: Skeletal mobility is largely dependent on the function of our joints. The thin hyaline cartilage layer covering our bones form cushions that allow us to comfortably perform all types of physical activities. Aside from these functions, healthy cartilage is required for normal skeletal development and throughout our lives protects bones from erosion, by functioning as a shock absorber during moderate or intense activity. Our lab is exploring the myriad roles of the endocannabinoid system and sirtuins within the the context of cartilage biology, during aging and skeletal development.

Key Words: Osteoarthritis, Metabolism, Sirt1, CB2, CB1, Synovitis, Joint, Meniscus, Endocannabinoid system.