Research Interest: Our laboratory is designing novel molecules targeting RNA, RNA-binding proteins, and disease-associated protein complexes to address unmet medical needs. We specialize in induced-proximity strategies, including molecular glues and bifunctional chimeras, to selectively modulate or eliminate pathogenic targets in cancer and other complex diseases. In the context of the Multidisciplinary Center for Cannabinoid Research, we focus on targeting the CB1 receptor and developing molecules that induce its selective degradation as a novel therapeutic approach for cancer and metabolic diseases associated with CB1R dysregulation.

Key Words: RNA targeting, RNA-binding proteins, induced proximity, targeted degradation, molecular glues, PROTACs, RIBOTACs, chemical biology, medicinal chemistry, cancer, metabolic diseases, Brain diseases, AI-guided drug discovery