Publication

 

2019

 

Baraghithy S, Smoum R, Attar-Namdar M, Mechoulam R, Bab I, Tam J (2019) HU-671, a Novel Oleoyl Serine Derivative, Exhibits Enhanced Efficacy in Reversing Ovariectomy-Induced Osteoporosis and Bone Marrow Adiposity. Molecules 24(20), 3719.

 

Udi S, Hinden L, Ahmad M, Drori A, Iyer MR, Cinar R, Herman-Edelstein M, Tam J (2019) Dual Inhibition of Cannabinoid-1 Receptor and iNOS Attenuates Obesity-induced Chronic Kidney Disease. Br J Pharmacol, doi: 10.1111/bph.14849.

 

El-Atawneh S, Hirsch S, Hadar R, Tam J, Goldblum A (2019) Prediction and Experimental Confirmation of Novel Peripheral Cannabinoid1 Receptor Antagonists. J Chem Inf Model, 59(9):3996-4006.

 

Braxton TM, Sarpong DE, Dovey JL, Guillou AT, Evans BT, Castellano JM, Keenan BE, Baraghithy S, Evans SL, Tena-Sempere M, Mollard P, Tam J, Wells T (2019) Thermoneutrality improves skeletal impairment in adult Prader-Willi syndrome mice. J Endocrinol, 243:175–186.

 

Friedman, L., Smoum, R., Feldman, M., Mechoulam, R. and Steinberg, D. (2019). Does the Endocannabinoid Anandamide Affect Bacterial Quorum Sensing, Vitality, and Motility?. Cannabis and Cannabinoid Research, 4(2), pp.102-109.

 

Petrie, G., Wills, K., Piscitelli, F., Smoum, R., Limebeer, C., Rock, E., Humphrey, A., Sheppard-Perkins, M., Lichtman, A., Mechoulam, R., Di Marzo, V. and Parker, L. (2019). Oleoyl glycine: interference with the aversive effects of acute naloxone-precipitated MWD, but not morphine reward, in male Sprague–Dawley rats. Psychopharmacology, 236(9), pp.2623-2633.

 

Stark, T., Ruda-Kucerova, J., Iannotti, F., D'Addario, C., Di Marco, R., Pekarik, V., Drazanova, E., Piscitelli, F., Bari, M., Babinska, Z., Giurdanella, G., Di Bartolomeo, M., Salomone, S., Sulcova, A., Maccarrone, M., Wotjak, C., Starcuk, Z., Drago, F., Mechoulam, R., Di Marzo, V. and Micale, V. (2019). Peripubertal cannabidiol treatment rescues behavioral and neurochemical abnormalities in the MAM model of schizophrenia. Neuropharmacology, 146, pp.212-221.

 

Donvito, G., Piscitelli, F., Muldoon, P., Jackson, A., Vitale, R., D'Aniello, E., Giordano, C., Ignatowska-Jankowska, B., Mustafa, M., Guida, F., Petrie, G., Parker, L., Smoum, R., Sim-Selley, L., Maione, S., Lichtman, A., Damaj, M., Di Marzo, V. and Mechoulam, R. (2019). N-Oleoyl-glycine reduces nicotine reward and withdrawal in mice. Neuropharmacology, 148, pp.320-331.

 

Mechoulam, R. ed., 2019. Cannabinoids as therapeutic agents. CRC Press.

 

Magid, L., Heymann, S., Elgali, M., Avram, L., Cohen, Y., Liraz-Zaltsman, S., Mechoulam, R. and Shohami, E. (2019). Role of CB2 Receptor in the Recovery of Mice after Traumatic Brain Injury. Journal of Neurotrauma, 36(11), pp.1836-1846.

 

Hirsch S, Tam J (2019) Cannabis: From a Plant That Modulates Feeding Behaviors toward Developing Selective Inhibitors of the Peripheral Endocannabinoid System for the Treatment of Obesity and Metabolic Syndrome. Toxins, 11(5): 275.

Aran A, Eylon M, Harel M, Polianski L, Nemirovski A, Tepper S, Schnapp A, Cassuto H, Wattad N, Tam J (2019) Lower Circulating Endocannabinoid Levels in Children with Autism Spectrum Disorder. Mol Autism, 10:2.

 

Hinden L, Tam J (2019) Do Endocannabinoids Regulate Glucose Reabsorption in the Kidney? Nephron,11:1-4.

 

Baraghithy S, Smoum R, Drori A, Hadar R, Gammal A, Hirsch S, Attar-Namdar M, Nemirovski A, Gabet Y, Langer Y, Pollak Y, Schaaf CP, Rech ME, Gross-Tsur V, Bab I, Mechoulam RTam J (2019) Magel2 Modulates Bone Remodeling and Mass in Prader Willi Syndrome by Affecting Oleoyl Serine Levels and Activity. J Bone Miner Res. 34:93-105.

 

​Azar S, Sherf-Dagan S, Nemirovski A, Webb M, Raziel A, Keidar A, Goitein D, Sakran N, Shibolet O, Tam J, Zelber-Sagi S (2019) Circulating Endocannabinoids Are Reduced Following Bariatric Surgery and Associated with Improved Metabolic Homeostasis in Humans. Obes Surg29:268-276.

 

Drori A, Permyakova A, Hadar R, Udi S, Nemirovski A, Tam J (2019) Cannabinoid-1 Receptor Regulates Mitochondrial Dynamics and Function in Renal Proximal Tubular Cells. Diabetes Obes Metab. 21:146-159.

 

 

2018

 

Zachut M, Kra G, Moallem U, Livshitz L, Levin Y, Udi S, Nemirovski A, Tam J (2018) Characterization of the Endocannabinoid System in Subcutaneous Adipose Tissue in Periparturient Dairy Cows and its Association to Metabolic Profiles. PLoS One., 13:e0205996.

 

Ganot N, Braitbard O, Gammal A, Tam J, Hochman J, Tshuva EY (2018) In Vivo Anticancer Activity of a Non‐Toxic Inert Phenolato Ti Complex: High Efficacy on Solid Tumors Alone and Combined with Pt Drugs. Chem Med Chem. 13:2290-2296.

 

Deis S, Srivastava RK, de Azua IR, Bindila L, Baraghithy S, Lutz B, Bab I, Tam J (2018) Age-related regulation of bone formation by the sympathetic cannabinoid CB1 receptor. Bone 108:34-42.

 

Hinden L, Udi S, Drori A, Gammal A, Nemirovski A, Hadar R, Baraghithy S, Permyakova A, Geron M, Cohen M, Tsytkin-Kirschenzweig S, Riahi Y, Leibowitz G, Nahmias Y, Priel ATam J (2018) Modulation of Renal GLUT2 by the Cannabinoid-1 Receptor: Implications for the Treatment of Diabetic Nephropathy. J Am Soc Nephrol, 29:434-448.

 

Azar S, Sherf-Dagan S, Nemirovski A, Webb M, Raziel A, Keidar A, Goitein D, Sakran N, Shibolet O, Tam J, Zelber-Sagi S (2018) Circulating Endoannabinoids Are Reduced Following Bariatric Surgery and Associated with Improved Metabolic Homeostasis in Humans. Obes Surg. doi: 10.1007/s11695-018-3517-0.  

 

Drori A, Permyakova A, Hadar R, Udi S, Nemirovski A, Tam J (2018) Cannabinoid-1 receptor regulates mitochondrial dynamics and function in renal proximal tubular cells. Diabetes Obes Metab. doi: 10.1111/dom.13497.

 

 

Hen-Shoval D, Amar S, Shbiro L, Smoum R, Haj CG, Mechoulam R, Zalsman G, Weller A, Shoval G (2018) Acute oral cannabidiolic acid methyl ester reduces depression-like behavior in two genetic animal models of depression. Behav Brain Res. 351:1-3.

 

Chiurchiù V, Leuti A, Smoum R, Mechoulam R, Maccarrone M (2018) Bioactive lipids ALIAmides differentially modulate inflammatory responses of distinct subsets of primary human T lymphocytes. FASEB J. doi: 10.1096/fj.201800107R.

 

 

Ibera C, Shalom B, Saifi F, Shruder J, Davidson E (2018) Effects of cannabis extract premedication on anesthetic depth. Harefuah. 157(3):162-166.

 

Abuhasira R, Schleider LB, Mechoulam R, Novack V (2018) Epidemiological characteristics, safety and efficacy of medical cannabis in the elderly. Eur J Intern Med. 49:44-50.

 

Bar-Lev Schleider L, Mechoulam R, Lederman V, Hilou M, Lencovsky O, Betzalel O, Shbiro L, Novack V (2018) Prospective analysis of safety and efficacy of medical cannabis in large unselected population of patients with cancer. Eur J Intern Med. 49:37-43.

 

Tam J, Hinden L, Drori A, Udi S, Azar S, Baraghithy S (2018) The therapeutic potential of targeting the peripheral endocannabinoid/CB1 receptor system. Eur J Intern Med. 49:23-29.

 

2017

 

Bilkei-Gorzo A, Albayram O, Draffehn A, Michel K, Piyanova A, Oppenheimer H, Dvir-Ginzberg M, Racz I, Ulas T, Imbeault S, Bab I, Schultze JL, Zimmer A (2017) A chronic low dose of Δ9-tetrahydrcannabinol (THC) restores cognitive function in old mice. Nat Med. 23(6):782-787.

 

Atsmon J, Cherniakov I, Izgelov D, Hoffman A, Domb AJ, Deutsch L, Deutsch F, Heffetz D, Sacks H (2017) PTL401, a New Formulation Based on Pro-nano Dispersion Technology, Improves Oral Cannabinoids Bioavailability in Healthy Volunteers. J Pharm Sci. 107(5):1423-1429.

 

Pertwee RG, Rock EM, Guenther K, Limebeer CL, Stevenson LA, Haj C, Smoum R, Parker LA, Mechoulam R (2017) Cannabidiolic acid methyl ester, a stable synthetic analogue of cannabidiolic acid, can produce 5-HT1A receptor-mediated suppression of nausea and anxiety in rats. Br J Pharmacol. 175(1):100-112.

 

Hinden L, Udi S, Drori A, Gammal A, Nemirovski A, Hadar R, Baraghithy S, Permyakova A, Geron M, Cohen M, Tsytkin-Kirschenzweig S, Riahi Y, Leibowitz G, Nahmias Y, Priel A, Tam J (2017) Modulation of Renal GLUT2 by the Cannabinoid-1 Receptor: Implications for the Treatment of Diabetic Nephropathy. J Am Soc Nephrol. 29(2):434-448.

 

Silva NR, Gomes FV, Fonseca MD, Mechoulam R, Breuer A, Cunha TM, Guimarães FS (2017) Antinociceptive effects of HUF-101, a fluorinated cannabidiol derivative. Prog Neuropsychopharmacol Biol Psychiatry. 79(Pt B):369-377. 

 

Wang Y, Mukhopadhyay P, Cao Z, Wang H, Feng D, Haskó G, Mechoulam R, Gao B, Pacher P (2017) Cannabidiol attenuates alcohol-induced liver steatosis, metabolic dysregulation, inflammation and neutrophil-mediated injury. Sci Rep. 7(1):12064. 

 

Cherniakov I, Izgelov D, Barasch D, Davidson E, Domb AJ, Hoffman A (2017) Piperine-pro-nanolipospheres as a novel oral delivery system of cannabinoids: Pharmacokinetic evaluation in healthy volunteers in comparison to buccal spray administration. J Control Release. 266:1-7.

 

Cherniakov I, Izgelov D, Domb AJ, Hoffman A (2017) The effect of Pro NanoLipospheres (PNL) formulation containing natural absorption enhancers on the oral bioavailability of delta- 9-tetrahydrocannabinol (THC) and cannabidiol (CBD) in a rat model. Eur J Pharm Sci. 109:21-30.

 

Udi S, Hinden L, Earley B, Drori A, Reuveni N, Hadar R, Cinar R, Nemirovski A, Tam J (2017) Proximal Tubular Cannabinoid-1 Receptor Regulates Obesity-induced Chronic Kidney Disease. J Am Soc Nephrol. 28(12):3518-3532. 


Tam J, Szanda G, Drori A, Liu Z, Cinar R, Kashiwaya Y, Reitman ML, Kunos G (2017) Peripheral Cannabinoid-1 Receptor Blockade Restores Hypothalamic Leptin Signaling. Mol Metab. 6(10):1113-1125.


Zelber-Sagi S, Azar S, Nemirovski A, Webb M, Halpern Z, Shibolet O, Tam J (2017) Serum levels of endocannabinoids are independently associated with nonalcoholic fatty liver disease. Obesity. 25(1):94-101.


Mechoulam R (2017) Cannabis and epilepsy. Epilepsy Behav. 70(Pt B):278-279.


Rock EM, Limebeer CL, Petrie GN, Williams LA, Mechoulam R, Parker LA (2017) Effect of prior foot shock stress and Δ9-tetrahydrocannabinol, cannabidiolic acid, and cannabidiol on anxiety-like responding in the light-dark emergence test in rats. Psychopharmacology (Berl) 234(14):2207-2217.

 

2016

Lee WS, Erdelyi K, Matyas C, Mukhopadhyay P, Varga ZV, Liaudet L, Haskó G, Čiháková D, Mechoulam R, Pacher P (2016) Cannabidiol limits T cell-mediated chronic autoimmune myocarditis: implications to autoimmune disorders and organ transplantation. Mol Med. 22:136-146.


Kozela E, Haj C, Hanuš L, Chourasia M, Shurki A, Juknat A, Kaushansky N, Mechoulam R, Vogel Z (2016) HU-446 and HU-465, Derivatives of the Non-psychoactive Cannabinoid Cannabidiol, Decrease the Activation of Encephalitogenic T Cells. Chem Biol Drug Des. 87(1):143-53.


Shoval G, Shbiro L, Hershkovitz L, Hazut N, Zalsman G, Mechoulam R, Weller A (2016) Prohedonic Effect of Cannabidiol in a Rat Model of Depression. Neuropsychobiology. 73(2):123-9.


Fisher T, Golan H, Schiby G, PriChen S, Smoum R, Moshe I, Peshes-Yaloz N, Castiel A, Waldman D, Gallily R, Mechoulam R, Toren A (2016) In vitro and in vivo efficacy of non-psychoactive cannabidiol in neuroblastoma. Curr Oncol. 23(2):S15-22.


Tam J (2016) The emerging role of the endocannabinoid system in the pathogenesis and treatment of kidney diseases. J Basic Clin Physiol Pharmacol. 27(3):267-76.


Mann A, Cohen-Yeshurun A, Trembovler V, Mechoulam R, Shohami E (2016) Are the endocannabinoid-like compounds N-acyl aminoacids neuroprotective after traumatic brain injury? J Basic Clin Physiol Pharmacol. 27(3):209-16.


Juknat A, Kozela E, Kaushansky N, Mechoulam R, Vogel Z (2016) Anti-inflammatory effects of the cannabidiol derivative dimethylheptyl-cannabidiol - studies in BV-2 microglia and encephalitogenic T cells. J Basic Clin Physiol Pharmacol. 27(3):289-96.


Maslov LN, Khaliulin I, Zhang Y, Krylatov AV, Naryzhnaya NV, Mechoulam R, De Petrocellis L, Downey JM (2016) Prospects for Creation of Cardioprotective Drugs Based on Cannabinoid Receptor Agonists. J Cardiovasc Pharmacol Ther. 21(3):262-72.


Mechoulam R (2016) Cannabis - the Israeli perspective. J Basic Clin Physiol Pharmacol. 27(3):181-7.


Shohami E, Horowitz M. Cannabinoids in Health and Disease (2016) J Basic Clin Physiol Pharmacol. 27(3):175-9.


Breuer A, Haj CG, Fogaça MV, Gomes FV, Silva NR, Pedrazzi JF, Del Bel EA, Hallak JC, Crippa JA, Zuardi AW, Mechoulam R, Guimarães FS (2016) Fluorinated Cannabidiol Derivatives: Enhancement of Activity in Mice Models Predictive of Anxiolytic, Antidepressant and Antipsychotic Effects. PLoS One. 11(7):e0158779.


Rock EM, Boulet N, Limebeer CL, Mechoulam R, Parker LA (2016) Cannabinoid 2 (CB2) receptor agonism reduces lithium chloride-induced vomiting in Suncus murinus and nausea-induced conditioned gaping in rats. Eur J Pharmacol. 786:94-9.


Knani I, Earley BJ, Udi S, Nemirovski A, Hadar R, Gammal A, Cinar R, Hirsch HJ, Pollak Y, Gross I, Eldar-Geva T, Reyes-Capo DP, Han JC, Haqq AM, Gross-Tsur V, Wevrick R, Tam J (2016) Targeting the endocannabinoid/CB1 receptor system for treating obesity in Prader-Willi syndrome. Mol Metab. 5(12):1187-1199.


Haroutounian S, Ratz Y, Ginosar Y, Furmanov K, Saifi F, Meidan R, Davidson E (2016) The Effect of Medicinal Cannabis on Pain and Quality-of-Life Outcomes in Chronic Pain: A Prospective Open-label Study. Clin J Pain. 32(12):1036-1043.